FibroGuard is a unique and potent mixture of bioflavonoids, polyphenols, spices, plant and berry extracts contained in the proprietary blend ATNF-10. Individually these ingredients are renowned for their antioxidant/anti-inflammatory/neuroprotective and cardiovascular protective effects. In FibroGuard, they have been combined to work in a cooperative fashion to also reduce the pro-inflammatory effects of the immune system in chronic inflammatory states. Many of these compounds have been found to decrease the levels of critical pro-inflammatory master cytokines such as TNF-Alpha and Interleukin Beta. Thus the mixture provides a multitude of health protective effects, not only enhancing antioxidant protection, but also specifically reducing the inflammatory activity of the immune system in chronic disease states.
Many bioflavonoids, plant extracts, and spices have been found to have significant beneficial effects on the human body; two major benefits are their antioxidant capabilities and their anti-inflammatory effects.
The antioxidant effects of flavonoids and polyphenol plant substances include: binding up toxic free radicals, preventing damage to the cell, protecting proteins from attacks by free radical and reactive oxygen species. They form this vital function by gently attaching to proteins forming a protective soft antioxidant mantle. They form this protective antioxidant layer with a much higher local concentration than regular water-soluble antioxidants like vitamin C, or the fat-soluble antioxidants like vitamin E and Lipoic acid. They are able to produce this effect because of their molecular properties: 1) the ring-like planes of the polyphenol molecules, and 2) the flexibility of the linkage between those rings, which allows tremendous flexibility in attaching gently to protein structures.
The immune system uses some of the most potent and destructive agents in the body in order to destroy harmful agents such as bacteria, viruses, and cancer cells. The actions of the immune system, (particularly of the oldest branch – the innate immune system, which uses mainly macrophages) are harmful to the cell’s own structures. Any overshooting activity beyond clearing invading microorganisms leads to the accumulation of chronic damage to tissues. Furthermore, the ancient signaling/communication system activates inflammatory defense mechanisms in regular organ cells, like heart and kidney when there is a remote inflammatory focus, like gum disease or a urinary tract infection. Activation of the innate immune response is like a wakeup call to prepare bodywide defenses against an infection yet to come. Even though the generalized infection seldom comes, the body is put in this activated state each time a small local inflammatory process is activated. Thus, the entire body suffers harm, and chronic damage is inflicted on the critical organs like heart, kidney, and brain; the glands such as the thyroid, pancreas and adrenals also suffer.
Thus while inflammation is part of the body’s immune system response to attack or injury, the immune system can often cause severe chronic diseases, like heart and kidney failure, hormone deficiencies and neurodegeneration. This self-destructive attack on the body occurs particularly when the counter-regulatory/brake-like mechanisms of the immune system are not working at optimum. We see this attack on healthy tissue, with the resultant disease and degeneration of body function, more frequently with advancing age as the body attacks on its own cells.
Additionally, the escalating chronic activation of the immune cells often causes increased levels of autoimmunity. Autoimmune attack may be the cause of many chronic inflammatory based diseases, such as chronic fatigue, fibromyalgia, Crohn’s disease, ulcerative colitis, cystic fibrosis, multiple sclerosis, and even chronic pulmonary and heart diseases.
Pharmaceutical agents have been developed which completely shut down TNF Alpha, and have been successfully used in many chronic inflammatory diseases. However their dollar cost is high and their complete blockage of TNF Alpha can result in immune system compromise and superinfection. Blocking TNF Alpha cripples certain arms of the immune system, leaving it incompetent to respond to some threats.
FibroGuard modulates the immune system by gently down regulating, without fully blocking, the function of inflammatory mediators such as TNF Alpha. And, of utmost importance, it stabilizes the oversensitive universal stress sensor of the body, Nuclear Factor Kappa B (NFKB). NFKB turns on hundreds of pro-inflammatory genes, including TNF Alpha and its receptors. Thus calming NFKB has far reaching effects. TNF Alpha and Interleukin 1 are the “master cytokines”, and NFKB is the master pro-inflammatory sensor and switch. Fibroguard stabilizes NFKB and prevents its over-activation, thereby reducing its overall pro-inflammatory signal and effect.
In short, FibroGuard allows the immune system to maintain its healthy protective role without becoming overactive.
FibroGuard is a complex and comprehensive formula containing the most researched and proven natural extracts and spices, with heavy emphasis on realistically tested extracts and critical polyphenols and flavonoids.
FibroGuard has been formulated using the highest quality ingredients available on the market today:
1) 99% pure crystalline resveratrol from Switzerland, the purest form of resveratrol available.
2) Bio-curcumin from India, the most researched and effective form of curcumin available.
3) Powergrape extract from France – the polyphenol rich Bordeaux grape extract shown to reduce protein oxidation and inflammation.
Copyright 2012 Hepatitis Technologies